Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > Allergies
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Bronchial Asthma - Principles of Diagnosis and Treatment (Paperback, Softcover reprint of the original 3rd ed. 1994)
Loot Price: R1,639
Discovery Miles 16 390
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Bronchial Asthma - Principles of Diagnosis and Treatment (Paperback, Softcover reprint of the original 3rd ed. 1994)
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Although the mechanisms and triggers that stimulate and are
responsible for the natural history ofasthma are steadily being
more clearly defined, uncertainties still surround both the genetic
basis and the etiologyofone of the most common syndromes in the
world. In fact, it is ofconsider- able concern and interest that
the incidence of asthma today appears to be rising. These
statistical increments may only reflect an increasing awareness of
the disease, or its earlier and more sophisticated diagnosis. More
important, however, asthma mortality appears to be increasing. This
increase has occurred despite the continuing expansion of a diag-
nostic and management information base, and the developmentofnovel
andevermoreeffective therapeutic modalities. Severalexplanations
have been offered for this increase in mortality, including that it
may result from a statistical artifact [based on a change in the
coding criteria for asthma from the International
ClassificationofDiseases Version 8(ICD- 8) to ICD-9], worsened
pollution, delays in seeking medical help, behav- ioral changes,
deficits in the asthma education of both patients and primary
careproviders, toxicity ofbeta-agonists, and noncompliance with
instructions for the proper use of medications. It should also be
empha- sized that the increases in both incidence and mortality may
be a reflec- tion of accumulating body burdens of environmental
toxicants and of increased oxidativedamage. There has clearly
beenadegradation ofenvi- ronmental quality. And although
considerableattention has been focused on this possibility in both
the scientific and lay press, more research in this area is
definitely needed.
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