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Tetracyclines in Biology, Chemistry and Medicine (Hardcover, 2001 ed.)
Loot Price: R4,489
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Tetracyclines in Biology, Chemistry and Medicine (Hardcover, 2001 ed.)
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The tetracyclines have an illustrious history as therapeutic agents
which dates back over half a century. Initially discovered as an
antibiotic in 1947, the four ringed molecule has captured the fancy
of chemists and biologists over the ensuing decades. Of further
interest, as described in the chapter by George Armelagos,
tetracyclines were already part of earlier cultures, 1500-1700
years ago, as revealed in traces of drug found in Sudanese Nubian
mummies. The diversity of chapters which this book presents to the
reader should illus trate the many disciplines which have examined
and seen benefits from these fascinating natural molecules. From
antibacterial to anti-inflammatory to anti autoimmunity to gene
regulation, tetracyclines have been modified and redesigned for
various novel properties. Some have called this molecule a biol
ogist's dream because of its versatility, but others have seen it
as a chemist's nightmare because of the synthetic chemistry
challenges and "chameleon-like" properties (see the chapter by S.
Schneider).
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