Down syndrome (DS) is the most common example of neurogenetic
aneuploid disorder leading to mental retardation. In most cases, DS
results from an extra copy of chromosome 21 (HSA21) producing
deregulated gene expression in brain that gives raise to subnormal
intellectual functioning. The topic of this volume is of broad
interest for the neuroscience community, because it tackles the
concept of neurogenomics, that is, how the genome as a whole
contributes to a neurodevelopmental cognitive disorders, such as
DS, and thus to the development, structure and function of the
This volume of Progress in Brain Research discusses comparative
genomics, gene expression atlases of the brain, network genetics,
engineered mouse models and applications to human and mouse
behavioral and cognitive phenotypes. It brings together scientists
of diverse backgrounds, by facilitating the integration of research
directed at different levels of biological organization, and by
highlighting translational research and the application of the
existing scientific knowledge to develop improved DS treatments and
Leading authors review the state-of-the-art in their field of
investigation and provide their views and perspectives for future
researchChapters are extensively referenced to provide readers with
a comprehensive list of resources on the topics coveredAll chapters
include comprehensive background information and are written in a
clear form that is also accessible to the non-specialist
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