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Molecular Machines (Hardcover)
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Molecular Machines (Hardcover)
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The studies of molecular machines and their application are very
active at this moment because of their long-standing prospective.
All that attention of the whole scientific community started with
the award of the Nobel Prize for Chemistry to John Walker and Paul
Boyer in 1997 for their work in elucidating the mechanism of the
rotary generator of ATP in the mitochondrion. The expected benefits
of their uses are now well known: ultimate size, possibility to
design finely-tuned molecular devices and their low energy
consumption. All above has inspired the design and synthesis of a
variety of compounds that resemble macroscopic machinery. This book
brought together different research works which discuss different
strategies to synthesize and study molecules demonstrating original
mechanical properties at the nanometre and at the atomic scale. The
book is divided on three parts, as the first one provides detailed
introduction to the field of molecular machines and motors, and
their advances and perspectives. The next part of the book
commences with a description of the functions of the molecular
motors, including kinesins and dyneins, as well as their putative
roles in Amyotrophic Lateral Sclerosis, after which R. Erickson et
al. presents the significant evidence that cargos in vivo are
carried by multiple motors. Three studies on molecular microtubule
motors then follow - by M. Gazzola et al., by K. Bartoli et al. and
by Z. Katsimitsoulia et al. This part ends with two articles which
discuss the structure and role of the bacterial flagellar motor.
The last third part gives a detailed review of real examples for
natural and artificial molecular machines used in the practise. The
area of knowledge for the molecular machine is expanding
continuously. Therefore, molecular machines for sensing, for
nucleotide recognition, and molecular machines involved in distinct
steps in neurotransmitter release are also discussed here.
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