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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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The Stressed Heart (Hardcover, 1987 ed.)
Loot Price: R2,996
Discovery Miles 29 960
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The Stressed Heart (Hardcover, 1987 ed.)
Series: Developments in Cardiovascular Medicine, 62
Expected to ship within 10 - 15 working days
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The Stressed Heart is truly unique in concept and will provide an
eXCItmg adventure to the reader no matter what his or her field of
expertise and interest. The title, although quite appropriate, does
not adequately indicate the range of topics considered or the
rational interrelationships among them. Indeed, perhaps the most
important point to be learned from the book is that a serious
consideration of the response of the heart to mechanical overload,
ischemia, or excessive humoral stimuli must include evaluation of
each of the topics in the table of contents. The heart responds to
stress through alterations in both structure and function. How
these changes are brought about is the subject of the initial
chapters. These consider first the normal regulation of gene
expression in the heart, the rapid response to mechanical overload
that leads to both quantitative and qualitative changes in the
contractile proteins, and our current understand ing of the signals
that might be elicited by stress and alter gene expression. One
chapter emphasizes the fact that, regardless of the nature of the
stress, the common denominator is a discrepancy between energy
requirements and expenditure. The central role of cellular acidosis
in initiating the sequence of responses to stress and the possible
roles of peptide regulators of transcription and protein regulators
of translation are considered in detail."
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