Breast cancer is often initiated by abnormal cellular mechanisms
and damage to DNA brought about by different types of cellular
stress. This book reviews the current standards of pathological
assessment of breast cancer specimens. There is a discussion of
recent molecular profiling studies in breast cancer and how our
view of the classification of breast cancer is changing. The
current role of molecular tests in the management of breast cancer
is also addressed, highlighting their strengths and limitations.
Additionally, it is widely acknowledged that the extracellular
matrix (ECM) of connective tissues plays active roles in numerous
biological processes such as cell differentiation, life/death
promotion and carcinogenesis. The studies on embryo-foetal collagen
type (OF/LB) and type V collagens are discussed and their putative
relevance in ductal infiltrating carcinoma (DIC) in-growth. This
book also assesses the level and determinants of knowledge about,
and risk factors for, breast cancer among women in the child
bearing period. A review of the literatures regarding the injection
sites of tracers in breast cancer sentinel lymph node (SLN) biopsy
is examined as well.
General
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