Contemporary immunobiology is an ever-diversifying field that
embraces many aspects of cellular and humoral immune
responsiveness. This includes the phylogeny, ontogeny, induction,
regulation, expression, and differentiation of the immune-cell
series, as well as the relationship of these to the pathogenesis of
many disease processes. It is clearly beyond the limitations of
each volume in this series to comprehensively cover progress in
each of these fields. Three general areas of contemporary
investigations are discussed in the current issue: cellular events
of B cell differentiation, including antigen recognition and respon
siveness of B lymphocytes; regulation of the immune response by T
cells, and the roles of this regulatory system in allotype
suppression and in autoimm unity; and the genetic control of immune
responses and its possible relation to disease pathogenesis.
Analysis of responsiveness of B lymphocytes has been greatly aided
by the availability of athymic nude mice. The immunological
responsiveness of these mice to a wide range of stimuli has been
reviewed and analyzed by H. H. Wortis. This article concludes with
the provocative thesis that in the future "nudes will supply new
rather than confirmatory data . . . (especially regarding) the
develop ment of neoplasia. " In contrast to the studies on the
congenitally athymic mice, G. F."
General
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