This book illustrates the intimate relationship between alveolar
macrophages and Mycobacterium tuberculosis (M.tb.), and the
former's role in both innate and adaptive immunity against M.tb. It
covers research done over the last decade. It also explores the
role of macrophage death following infection with M.tb. in
determining whether successful immunity is stimulated, or whether
clinical disease develops; furthermore, the function of host lipid
mediators in macrophage death modality are addressed. The book also
illustrates how the balance between prostaglandins and lipoxins
determines whether infected macrophages undergo apoptosis or
necrosis, which is the ultimate factor in the outcome of infection.
Finally, it is a synthesis of the authors' recent studies and the
studies of others to offer a new understanding of immunity to
tuberculosis.
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