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Research Progress in Alzheimer's Disease & Dementia, Volume 2 (Hardcover)
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Research Progress in Alzheimer's Disease & Dementia, Volume 2 (Hardcover)
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Alzheimer's disease (AD), the most common type of neurodegenerative
disorder in the aging population, is characterised pathologically
by extracellular amyloid plaques and intracellular neurofibrillary
tangles, pathophysiologically by synaptic dysfunction, and
clinically by a progressive dementia. The rapid progress in the
research fields of AD and dementia continues since the publication
of the first book volume with the same title. This second book
volume contains 14 chapters, bringing together a presentation of
research frontiers in current AD/dementia research. The topics
range from defining deregulation of amyloid precursor protein (APP)
processing and neurotransmitter and signal molecules involved in
regulation of APP processing, transgenic AD mouse models and their
relevance to AD research, amyloid -peptide (A) immunisation,
cerebral inflammation, myelin breakdown, roles of deregulation of
cell cycle in AD pathology, relationship between cholesterol and
AD, A binding to cholesterol and cholesterol oxidation, A-binding
alcohol dehydrogenase and roles in AD pathogenesis, sex steroids,
oestrogen therapy for AD prevention, behavioural and psychological
symptoms of AD, memantine for AD therapy, enoxaparin as a
therapeutic agent for AD, to molecular links between AD and
traumatic brain injury. The prospects for developing effective
therapeutic agents that target memory-relevant AD pathogenesis, as
shown in these chapters written by world-wide leaders in the
fields, are more encouraging. The book will be highly valuable to
students and scientists world-wide who are interested in the
scientific research progress in AD and dementia.
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