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Introduction to Perfusion Quantification using Arterial Spin Labelling (Paperback)
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Introduction to Perfusion Quantification using Arterial Spin Labelling (Paperback)
Series: Oxford Neuroimaging Primers
Expected to ship within 12 - 17 working days
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Arterial Spin Labeling (ASL) is an increasingly popular tool to
study the brain. What sets it apart from other neuroimaging methods
is the combination of quantitative measurements of a
physiologically well-defined process, namely perfusion, and a
completely non-invasive acquisition methodology. Cerebral perfusion
is a critical component to brain health, as it is the primary means
to deliver nutrients to support brain function as well as clearing
waste products. Hence it is a useful quantity to study in disease
where changes in perfusion can indicate regions of the brain that
are pathological. Likewise changes in perfusion can be indicative
of greater demand for nutrients, such as might be required in
response to an increase in neuronal activity. With the advent of a
consensus by the ASL community on good practice and a
recommendation on robust methods for ASL data collection, more and
more researchers are now able to access and use ASL. Despite the
technological advances, ASL remains a technique with a low signal
to noise ratio. This makes the wise choice of the appropriate
analysis methods more important. The aim of this primer is to equip
someone new to the field of perfusion imaging and ASL with the
knowledge not only to make good choices about ASL acquisition and
analysis, but also to understand what choices they are making and
why. Examples of analysis applied to real data are given throughout
the text and instructions on how to reproduce the analyses are
illustrated on the primer website. Written to provide a stand-alone
introduction to perfusion qualification using ASL, this primer also
works with other texts in the Oxford Neuroimaging Primers series to
provide a comprehensive overview of the increasingly influential
field of neuroimaging.
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