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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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EDHF - The Complete Story (Paperback)
Loot Price: R1,307
Discovery Miles 13 070
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EDHF - The Complete Story (Paperback)
Expected to ship within 10 - 15 working days
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The advances made in vascular biology in the last 25 years have
considerably changed the perception that one could have of the
endothelial cells. Once considered as a diffusion barrier
preventing the access of the blood cells to the vascular matrix,
the endothelium is now recognized as playing a major role in the
control of blood fluidity, platelet aggregation, and vascular tone,
but also in immunology, inflammation, angiogenesis, and for serving
as a metabolizing and an endocrine organ. -- from the preface
Cardiovascular diseases, so prevalent in the Western world during
the twentieth century, could well become the scourge of the
twenty-first century in emerging countries as well as the West.
Endothelial dysfunction linked to an imbalance in the synthesis
and/or release of contracting and relaxing factors is often evoked
to explain the initiation of the cardiovascular pathology or its
development and perpetuation. Two decades ago, when nitric oxide
was demonstrated to mediate endothelium-dependent relaxations, the
vascular world seemed convinced that nitric oxide was the ultimate
and sole explanation for such relaxations. However not everyone
agreed. EDHF: The Complete Story is the work of two leading
researchers who did not accept that simple conclusion, but instead
continued to search, along with others, for a deeper understanding
of the ways in which endothelial cells communicate with the
underlying smooth muscle to signal it to hyperpolarize. Now with
most, if not all, of those ways, uncovered, the authors offer this
summary as way of bringing closure to the quest. This monograph
reports on the work of many researchers. It summarizes the
significant recent discoveries concerning endothelium-dependent
hyperpolarizations, which are likely to play a much more important
role in cardiovascular physiology and pathology than was originally
foreseen Extensively illustrated with original diagrams and
schematics that su
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