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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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EDHF - The Complete Story (Hardcover)
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EDHF - The Complete Story (Hardcover)
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The advances made in vascular biology in the last 25 years have
considerably changed the perception that one could have of the
endothelial cells. Once considered as a diffusion barrier
preventing the access of the blood cells to the vascular matrix,
the endothelium is now recognized as playing a major role in the
control of blood fluidity, platelet aggregation, and vascular tone,
but also in immunology, inflammation, angiogenesis, and for serving
as a metabolizing and an endocrine organ.
-- from the preface
Cardiovascular diseases, so prevalent in the Western world during
the twentieth century, could well become the scourge of the
twenty-first century in emerging countries as well as the West.
Endothelial dysfunction linked to an imbalance in the synthesis
and/or release of contracting and relaxing factors is often evoked
to explain the initiation of the cardiovascular pathology or its
development and perpetuation. Two decades ago, when nitric oxide
was demonstrated to mediate endothelium-dependent relaxations, the
vascular world seemed convinced that nitric oxide was the ultimate
and sole explanation for such relaxations. However not everyone
agreed.
EDHF: The Complete Story is the work of two leading researchers who
did not accept that simple conclusion, but instead continued to
search, along with others, for a deeper understanding of the ways
in which endothelial cells communicate with the underlying smooth
muscle to signal it to hyperpolarize. Now with most, if not all, of
those ways, uncovered, the authors offer this summary as way of
bringing closure to the quest.
This monograph reports on the work of many researchers. It
summarizes the significant recent discoveries concerning
endothelium-dependent hyperpolarizations, which are likely to play
a much more important role in cardiovascular physiology and
pathology than was originally foreseen
Extensively illustrated with original diagrams and schematics that
summarize the different steps of endothelium-dependent
hyperpolarization, the text is designed for vascular biologists,
and cardiologists, as well as graduate students looking to gain an
understanding of the intimate functioning of the blood vessel wall.
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