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Structural and Mediator Lipidomics (Paperback)
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Structural and Mediator Lipidomics (Paperback)
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Lipidomics forms part of the field of metabolomics, which in turn
follows on from genomics, transcriptomics, and proteomics, in a
top-down manner. It is the study of hydrophobic molecules called
lipids; however, lipid molecular species are so numerous that
investigators tend to subdivide global lipidomics into targeted
lipidomic approaches. This book focuses on structural and mediator
lipidomics, with a particular emphasis on their functional aspects.
This includes lipids deserving of special interest for their
structures (especially as parts of cell membranes or plasma
lipoprotein particles) and lipids known for their biological
activities, which mediate the action of cell agonists (for example,
hormones, growth factors, etc.). The oxygenated metabolites of the
major functional w6 and w3 polyunsaturated fatty acids in mammals,
in particular arachidonic and docosahexaenoic acids, are presented,
with special attention paid to their structure-function
relationships. These metabolites are very active, and their
biological relevance was recognized early on with a Nobel Prize in
Physiology and Medicine in 1982. Finally, general principles for
the high performance analysis and characterization of lipid species
are also presented. The book has been written for undergraduate
students and scientists interested in the field of lipids.
Clinicians will also be able to find useful information, due to the
numerous references to pathophysiology.
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