Organ Directed Toxicities of Anticancer Drugs - Proceedings of the First International Symposium on the Organ Directed Toxicities of the Anticancer Drugs Burlington, Vermont, USA-June 4-6, 1987 (Paperback, Softcover Repri)

The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in tervention. Much of this toxicity, such as damage to the bone marrow, gastroin testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre dicted toxicities are usually irreversible or only partially reversible upon cessation of drug administration. Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Developments in Oncology, 53
Release date:	November 2011
First published:	1988
Editors:	Miles P. Hacker • John S Lazo • Thomas R. Tritton
Dimensions:	235 x 155 x 14mm (L x W x T)
Format:	Paperback
Pages:	254
Edition:	Softcover Repri
ISBN-13:	978-1-4612-9205-0
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	1-4612-9205-0
Barcode:	9781461292050

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