From asthma to Crohn's disease, everyone knows someone who suffers
from an allergic or autoimmune disorder. And if it appears that the
prevalence of these maladies has increased recently, that's because
it has--to levels never before seen in human history. These days no
fewer than one in five--and likely more--Americans suffers from one
of these ailments. We seem newly, and bafflingly, vulnerable to
immune system malfunction. Why? One possibility is that we have
systematically cleaned ourselves to illness; this belief challenges
deeply entrenched notions about the value of societal hygiene and
the harmful nature of microbes. Yet scientists investigating the
rampant immune dysfunction in the developed world have inevitably
arrived at this conclusion. To address this global "epidemic of
absence," they must restore the human ecosystem.
This groundbreaking book explores the promising but controversial
"worm therapy"--deliberate infection with parasitic worms--in
development to treat autoimmune disease. It explains why farmers'
children so rarely get hay fever, why allergy is less prevalent in
former Eastern Bloc countries, and how one cancer-causing bacterium
may be good for us. It probes the link between autism and a
dysfunctional immune system. It investigates the newly apparent
fetal origins of allergic disease--that a mother's inflammatory
response imprints on her unborn child, tipping the scales toward
allergy.
"An Epidemic of Absence" is a brilliant, cutting-edge exploration
of the dramatic rise of allergic and autoimmune diseases and the
controversial, potentially groundbreaking therapies that scientists
are developing to correct these disorders.
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