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RNAi Screening - Growth and Metabolism in Drosophila melanogaster (Paperback)
Loot Price: R2,093
Discovery Miles 20 930
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RNAi Screening - Growth and Metabolism in Drosophila melanogaster (Paperback)
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Total price: R2,113
Discovery Miles: 21 130
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The fruit fly, Drosophila melanogaster, is one of the famous model
system used to understand various aspects of life. This is largely
due to several reasons like its short life cycle, easy handling,
fully sequenced genome and a wide array of available tools. These
important genetics tools exploited are discussed in this book to
unravel the biological mysteries of growth and metabolism. The
evolutionary conserved insulin and nutrient signaling network is
centered on TOR kinase. The TOR kinase and its substrate S6 kinase
(S6K) orchestrate cell-autonomous and hormone-controlled growth and
also controls the metabolism. The author beautifully describes a
genome wide RNAi screen for novel regulators of steroidogenesis,
lipid metabolism and dS6K-dependent growth. He presents a novel
protein-protein interaction growth network in Drosophila and,
through molecular data he shows that archipelago (ago), a component
of an SCF-ubiquitin ligase known to regulate the degradation of
dMyc, Cyclin E and Notch, regulates dS6K degradation. This book
emphasizes the importance of the saturating screening strategies to
identify novel regulators of the signaling pathways in Drosophila.
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