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Current Applications for Overcoming Resistance to Targeted Therapies (Book, 1st ed. 2019)
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Current Applications for Overcoming Resistance to Targeted Therapies (Book, 1st ed. 2019)
Series: Resistance to Targeted Anti-Cancer Therapeutics, 20
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Targeted therapies were initially developed to exploit the
upregulation and dependence on key oncogenic pathways critical to
cancer progression. Additionally, they also presented as a method
to overcome chemoresistance by supplementing conventional
therapeutic regimens with targeted therapies. However, the
development of resistance to these combinatorial approaches has led
to the reassessment of currently available therapeutic options to
overcome resistance to targeted therapy. This book aims to provide
an update on the advancements in the therapeutic arms race between
cancer, clinicians and scientists alike to overcome resistance to
targeted therapies. Subject experts provide a comprehensive
overview of the challenges and solutions to resistance to several
conventional targeted therapies in addition to providing a
discussion on broad topics including targeting components of the
tumor microenvironment, emerging therapeutic options, and novel
areas to be explored concerning nanotechnology and the epigenome.
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