Metal ions and metal complexes have long been recognized as
critically important components of nucleic acid chemistry, both in
regulation of gene expression and as promising therapeutic agents.
Understanding how metal complexes interact with DNA has become an
active research area at the interface between chemistry, molecular
biology and medicine.
"Metal Complex - DNA Interactions" provides a comprehensive
overview of this increasingly diverse field, presenting recent
developments and the latest research with particular emphasis on
metal-based drugs and metal ion toxicity. The text is divided into
four parts: "Basic Structural and Kinetic Aspects: " includes
chapters on sequence-selective metal binding to DNA and
thermodynamic models. "Medical Applications: " focuses on
anticancer platinum drugs, including discussions on DNA repair in
antitumor effects of platinum drugs and photo-dynamic
therapy."DNA-Recognition - Nucleases and Sensor" describes probes
for DNA recognition, artificial restriction agents,
metallo-DNAzymes for metal sensing applications and metal ion
dependent catalysis in nucleic acid enzymes."Toxicological Aspects:
" deals with structural studies of mercury-DNA interactions,
chromium-induced DNA damage and repair, and the effect of arsenic
and nickel on DNA integrity.
This book will be a valuable resource for academic researchers
and professionals from a range of pharmaceutical and chemical
industries, particularly those involved in the development of new
and less toxic anticancer metallo-drugs, and in the field of
environmental and toxicological chemistry.
General
| Imprint: |
Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
|
| Country of origin: |
United Kingdom |
| Release date: |
March 2009 |
| First published: |
May 2009 |
| Authors: |
N. Hadjiliadis
|
| Dimensions: |
253 x 174 x 35mm (L x W x T) |
| Format: |
Hardcover
|
| Pages: |
544 |
| Edition: |
New |
| ISBN-13: |
978-1-4051-7629-3 |
| Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
General
|
| LSN: |
1-4051-7629-6 |
| Barcode: |
9781405176293 |
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