Anti-native DNA antibodies and DNA are present in cryopreClpItates
from patients with systemic lupus erythematosus and some other
cryoglob ulinemic states. The data suggest that these antibodies
may be bound in immune complexes. The demonstration of native DNA
in these precipitates raises the likelihood that they represent
specific antigen in these complexes. Whether or not these complexes
play a pathogenetic role in nonlupus inflammatory diseases remains
to be demonstrated. References Aarden, L. A., de Groot, E. R., and
Feltkamp, T. E. W., 1975, Immunology of DNA. III. Crithidia
luciliae, a simple substrate for the determination of anti-dsDNA
with the immu nofluorescence technique, Ann. N.Y. A cad. Sci.
254:505. Agnello, V., Winchester, R. J. and Kunkel, H. G., 1970,
Precipitin reactions of the Clq component of complement with
aggregated 'Y-globulin and immune complexes in gel diffusion,
Immunology 19:909. Anker, P., Stroun, M., and Maurice, P. A., 1975,
Spontaneous release of DNA by human blood lymphocytes as shown in
an in vitro system, Cancer Res. 35:2375. Bankhurst, A. D., and
Williams, R. C., 1975, Identification of DNA-binding lymphocytes in
patients with systemic lupus erythematosus, ]. Clin. Invest.
56:1378. Bluestone, R., Goldberg, L. S., Cracchiolo, A., and
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39:16."
General
| Imprint: |
Springer-Verlag New York
|
| Country of origin: |
United States |
| Release date: |
December 2012 |
| First published: |
1983 |
| Editors: |
Nancy Cummings
|
| Dimensions: |
244 x 170 x 31mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
564 |
| Edition: |
Softcover reprint of the original 1st ed. 1983 |
| ISBN-13: |
978-1-4613-4627-2 |
| Categories: |
Books >
Medicine >
Clinical & internal medicine >
Renal medicine >
General
Promotions
|
| LSN: |
1-4613-4627-4 |
| Barcode: |
9781461346272 |
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