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Integrating Clinical Research into Epidemic Response - The Ebola Experience (Paperback)
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Integrating Clinical Research into Epidemic Response - The Ebola Experience (Paperback)
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The 2014?2015 Ebola epidemic in western Africa was the longest and
most deadly Ebola epidemic in history, resulting in 28,616 cases
and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola
virus has been known since 1976, when two separate outbreaks were
identified in the Democratic Republic of Congo (then Zaire) and
South Sudan (then Sudan). However, because all Ebola outbreaks
prior to that in West Africa in 2014?2015 were relatively isolated
and of short duration, little was known about how to best manage
patients to improve survival, and there were no approved
therapeutics or vaccines. When the World Heath Organization
declared the 2014-2015 epidemic a public health emergency of
international concern in August 2014, several teams began
conducting formal clinical trials in the Ebola affected countries
during the outbreak. Integrating Clinical Research into Epidemic
Response: The Ebola Experience assesses the value of the clinical
trials held during the 2014?2015 epidemic and makes recommendations
about how the conduct of trials could be improved in the context of
a future international emerging or re-emerging infectious disease
events. Table of Contents Front Matter Summary 1 Introduction 2
Conducting Clinical Research During an Epidemic 3 Assessment of
Therapeutic Trials 4 Assessment of Vaccine Trials 5 Strengthening
Capacity for Response and Research 6 Engaging Communities in
Research and Response 7 Facilitating International Coordination and
Collaboration Appendix A: Study Approach and Methods Appendix B:
Clinical Trial Designs Appendix C: Ethical Principles for Research
with Human Subjects Appendix D: Biographical Sketches of Committee
Members and Staff
General
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