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Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine - Proceedings of a Workshop (Paperback)
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Discovery Miles 11 910
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Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine - Proceedings of a Workshop (Paperback)
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Precision medicine is focused on the individual and will require
the rapid and accurate identification and prioritization of
causative factors of disease. To move forward and accelerate the
delivery of the anticipated benefits of precision medicine,
developing predictable, reproducible, and reliable animal models
will be essential. In order to explore the topic of animal-based
research and its relevance to precision medicine, the National
Academies of Sciences, Engineering, and Medicine convened a 2-day
workshop on October 5 and 6, 2017. The workshop was designed to
focus on the development, implementation, and interpretation of
model organisms to advance and accelerate the field of precision
medicine. Participants examined the extent to which next-generation
animal models, designed using patient data and phenotyping
platforms targeted to reveal and inform disease mechanisms, will be
essential to the successful implementation of precision medicine.
This publication summarizes the presentations and discussions from
the workshop. Table of Contents Front Matter 1 Introduction to
Precision Medicine and Animal Models 2 Existing Precision Medicine
Initiatives 3 The Promise and Perils of Animal Models 4
Reproducibility and Predictivity 5 In Vitro Alternatives to Animal
Models 6 Assessing Safety and Toxicology 7 Patient Perspectives 8
Reflections on the Workshop References Appendix A: Agenda Appendix
B: Planning Committee Biographies Appendix C: Speaker Biographies
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