This fifth volume of Research Methods in Neurochemistry represents
a milestone in that it marks almost a decade since the inception of
the series. Over these ten years there has been an almost
exponential growth in neuro chemistry accompanied by numerous
technical developments. This is the justification for our series;
inevitably we have only been able to cover a frac tion of the
methodological innovations of the last decade, but we have tried as
much as possible to create a balance between the different
approaches and philosophies in the study of the chemical basis of
brain function. Thus our original format of grouping chapters under
various headings-for instance, studies in intact tissues as
distinct from studies describing constituents and isolated
enzymes-appears to be justified. Studies on whole animals or
tissues retaining cellular organization are vital in providing
insights into the neurochemical mechanism underlying functional
processes; at the same time, the eventual understanding of function
can only be attained on the basis of knowledge of the molecular
architecture of the tissue. In the present volume, Oldendorfs
chapter on the transport of radiolabeled metabolites across the
blood-brain barrier illustrates one side of this equation, whereas
Poduslo's chapter on the separation of oligo dendroglia cells
provides new information on the role of these cells in myelogenesis
and the distinctive chemical composition of glia as compared to
neurons."
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