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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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The Immunogenetics of Dermatologic Diseases (Hardcover, 1st ed. 2022)
Loot Price: R4,351
Discovery Miles 43 510
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The Immunogenetics of Dermatologic Diseases (Hardcover, 1st ed. 2022)
Series: Advances in Experimental Medicine and Biology, 1367
Expected to ship within 10 - 15 working days
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This book intends to investigate the broad spectrum of genetic
changes in immunological processes involved in cutaneous diseases.
One of the main goals of immunogenetic studies is finding
susceptibility genes for complex diseases. This can provide an
insight into the pathogenesis of the condition in a way that is not
easily achievable through other kinds of studies. Thus they are a
rational initial step for generating hypotheses about disease
pathogenesis. This may especially benefit dermatology, a field
notorious for having too many diseases with unknown etiologies.
Immunogenetic investigations have made targeted treatment
strategies possible for diseases such as psoriasis and pemphigus.
Even though these strategies have revolutionized the management of
chronic dermatological conditions such as psoriasis, still there
are a lot of unanswered questions. For instance, psoriasis patients
respond very differently to each of the commercially available
biological agents. This diversity could be partially explained by
the differences in the sets of genes responsible for disease
induction in each individual. Thus whole genome sequencing
strategies, if feasible at individual levels, might help in
tailoring these targeted treatments based on specific genetic
backgrounds. Our intention in preparing this book was to explore
the broad spectrum of the genetic aspects of immunological
processes involved in cutaneous diseases. We have tried to cover
most areas of dermatology where enough studies were available to
gather a chapter. Still, there is a substantial lack of knowledge
on the immunogenetics of many dermatological conditions. We hope
that this book would encourage the investigators to fill these gaps
of knowledge.
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