First published in 1987, this book is about how cells
differentiate; that is it describes the way in which cells in
animal and plant bodies take on their specialised fates. It has
long been recognised that since all such cells retain copies of all
genes, the genetic explanation for tissue differences lies in the
controlled expression of restricted sets of genes. But how is the
choice made and how are such restricted groups of genes activated
and regulated? This book discusses these questions and describes
both determination and differentiation. The mechanisms that
underlie the processes are described for the embryo and in the
adult. Determination may occur in adult life during regeneration,
wound healing, cancer formation and in the immune and blood
systems, and the possible genetic basis for the events is explored.
The influence of the cell environment, the cell surface and the
pericellular-extracellular matrix as mediators of external signals
is discussed.
General
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