Iminosugars form undoubtedly the most attractive class of
carbohydrate mimics reported so far. In these structures, the
substitution of the endocyclic oxygen of sugars by a basic nitrogen
atom leads to remarkable biological properties and raises many
challenges in organic synthesis. Since the discovery of their
biological activity as glycosidase inhibitors in the 1970's, these
polyvalent molecules have progressively made their way from the
laboratory to the clinic.
The impressive series of discoveries in the field over the past
ten years indicates clearly that it is "a boom time" for iminosugar
chemistry and biology. The scope of their profile as inhibitors has
been extended to a number of enzymes such as phosphorylases,
glycosyltransferases or metalloproteinases, and iminosugars now
constitute lead compounds for the development of new therapeutic
agents for a wide range of diseases including diabetes, viral
infections, lysosomal storage disorders and tumor metastasis.
Latest developments, from iminosugar synthesis to their use in
clinical studies, are presented in this book, which contains
contributions from over fifteen of the major chemists, biochemists
and drug developers in this rapidly expanding field. An extensive
table correlating the structures of more than 600 iminosugars of
therapeutic interest with their biological activities is also
included in the book and should prove particularly useful to aid
with the design and the discovery of novel bioactive
substances.
"Iminosugars: From Synthesis to Therapeutic Application"
provides a unique resource for academic and industrial researchers
working in the field of iminosugars and glycomimetics of biological
and/ortherapeutic interest: organic chemists, medicinal chemists,
carbohydrate chemists and medical scientists.
General
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