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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Growth Factors and the Cardiovascular System (Hardcover, 1993 ed.)
Loot Price: R5,631
Discovery Miles 56 310
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Growth Factors and the Cardiovascular System (Hardcover, 1993 ed.)
Series: Developments in Cardiovascular Medicine, 147
Expected to ship within 10 - 15 working days
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Nature is totally amoral! There are at least 3-4 million people in
France alone who suffer from arterial hypertension, and whose
cardiovascular system is submitted day and night to both a
haemodynamic and hormonal stress. In all cases, the vasculature
hypertrophies as does the myocardium. This growth process is
obviously mainly detrimental at the outset since it lowers
compliance of the arteries and makes them stiffer. In contrast,
myocardial hypertrophy is initially beneficial since the growth
process multiplies the number of contractile units and by so doing
improves external work. In addition, according to Starling's law,
wall stress is lowered. Growth factors playa major role in this
amoral process as a trigger for hypertrophy at the vascular level,
and very likely at the level of the myocardium. Another major point
of interest is the role of growth factors as determinants of
restenosis after angioplasty and also of atherogenesis. Several
chapters in this book are directly or indirectly concerned with
this problem which is far from being purely academic since several
groups are currently trying to control these processes by gene
transfer. Certainly, one of the major clinical questions arising
from such studies is why restenosis is not more frequent in
clinical practice. After de-endotheliazation, the biologist would
predict on the basis of recent studies on growth factors, and in
contrast with current clinical opinion, that hypertrophy would
occur in all cases with more or less complete restenosis.
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