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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Carcinogenesis (Paperback, Softcover reprint of the original 1st ed. 1979)
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Carcinogenesis (Paperback, Softcover reprint of the original 1st ed. 1979)
Series: Current Topics in Pathology, 67
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1. Concepts on the Causal Genesis of Human Intestinal Tumors The
action of chemical substances has a significant role in the genesis
of human tumors. It is assumed that most human tumors are induced
by exogenous chemical noxae (Schmahl, 1970;Heidelberger, 1975; and
others). In the course of intensive efforts to discover the
principles of tumor etiology, important insights have resulted in
recent years. These are that chemical carcinogens do not only arise
as products of our tech nological civilization, but that they also
occur in nature as potent solitary carcinogens and cocarcinogens
(e. g., as plant products). For review, see Hecker (1972) and
Preuss mann (1975). Not only "complete" carcinogens are significant
for the genesis of tu mors, but also substances which are first
transformed to the actual carcinogenic com pound in the organism
(Schmahl, 1975). The causal significance of exogenous noxae in
carcinogenesis is indicated by the fact emphasized by Bauer (1963)
that malignant tumors occur predilectively at those sites in the
body which are in direct or indirect contact with the environment.
This applies especially to the intestinal tract."
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