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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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The Metabotropic Glutamate Receptors (Paperback, Softcover reprint of hardcover 1st ed. 1995)
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The Metabotropic Glutamate Receptors (Paperback, Softcover reprint of hardcover 1st ed. 1995)
Series: The Receptors
Expected to ship within 10 - 15 working days
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It is the goal of The Metabotropic Glutamate Receptors to provide
acomprehensive and forward-thinking review ofthe tremen- dous
advances that have occurred in less than a decade of metabotropic
glutamate receptors (mGluR) research. Virtually every areaof mGluR
research is covered, including the molecular biology, pharmacology,
anatomical distribution, and physiological and pathological roles
of mGluRs. It is our intention that this volume not only summarize
what is now known about the mGluRs, but also illuminate the areas
in which there is the greatest need for focused research. Glutamic
acid is an amino acid that has long been known to play several
important metabolic roles in central and peripheral tissues and to
be a component of several naturally occurring molecules. The first
evidence that glutamate mayaIso serve as a neurotransmitter in the
central nervous system (CNS) came in the late 1950s and early 1960s
when glutamate and other acidic amino acids were found to induce
behavioral convulsions when topically applied to the cortex and to
excite a wide variety of central neurons. These findings spurred a
massive research effort that quickly established glutamate as the
pri- mary excitatory neurotransmitter in the vertebrate CNS. One of
the most striking characteristics of glutamate that was quickly
recognized was its ubiquitous role in serving as the
neurotransmitter at the vast majority of excitatory synapses in the
brain. It is now clear that most central neuronal circuits involve
glutamatergic neurotransmission at some level.
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