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Concepts in Biochemical Pharmacology - Part 3 (Paperback, Softcover reprint of the original 1st ed. 1975)
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Concepts in Biochemical Pharmacology - Part 3 (Paperback, Softcover reprint of the original 1st ed. 1975)
Series: Handbook of Experimental Pharmacology, 28 / 3
Expected to ship within 10 - 15 working days
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Part 3 of the Handbook of Experimental Pharmacology (Concepts in
Biochem ical Pharmacology) applies the principles enunciated in
Parts 1 and 2 to clinical pharmacology and toxicology. The major
objective is to elucidate the many factors that determine the
relationships between pharmacokinetic aspects of the disposition
and metabolism of drugs and their therapeutic or toxic actions in
man. Because of the more restricted information obtainable in human
studies, this volume reflects the editors' bias that an
understanding of pharmacokinetics is fundamental for assessing
pharmacologic or toxicologic effects of drugs in humans. The first
chapter is a unique primer on when to apply and how to use pharmaco
kinetic tools in human pharmacology. The second chapter explains
the general assumptions underlying pharmacokinetic approaches both
in simple terms for the novice and in mathematical form for the
more sophisticated reader. Several chapters on determinants of drug
concentration and activity discuss drug absorption, drug
latentiation, drugs acting through metabolites, entero hepatic drug
circulation, influence of route of drug administration on response,
genetic variations in drug disposition and response, age
differences in absorption, distribution and excretion of drugs, and
pathologic and physiologic factors affecting absorption,
distribution and excretion of drugs and drug response. The focus of
these chapters is data obtained in human, rather than animal,
studies. Most of the chapters contain new material never summarized
previously."
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