The Medicinal Chemist's Guide to Solving ADMET Challenges
summarizes a series of design strategies and tactics that have been
successfully employed across pharmaceutical and academic
laboratories to solve common ADMET issues. These are exemplified
with a curated collection of concrete examples displayed in a
highly visual "table-of-contents" style format, allowing readers to
rapidly identify the most promising approaches applicable to their
own challenges. Each ADMET parameter is introduced in a concise yet
comprehensive manner and includes background, relevance and
screening strategies. Medicinal chemistry knowledge of how best to
modify molecular structure to solve ADMET issues is challenging to
retrieve from the literature, public databases and even corporate
data warehouses. The Medicinal Chemist's Guide to Solving ADMET
Challenges addresses this gap by presenting state-of-the-art design
strategies put together by a global group of experienced medicinal
chemists and ADMET experts across academia and the pharmaceutical
industry.
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