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Receptor - Based Drug Design (Paperback)
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Receptor - Based Drug Design (Paperback)
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Employing a wide range of examples from G-protein-coupled receptors
and ligand-gated ion channels, this detailed, single-source
reference illustrates the principles of pharmacological analysis
and receptor classification that are the basis of rational drug
design. Explains the experimental and theoretical methods used to
characterize interactions between ligands and receptors-providing
the pharmacological information needed to solve treatment problems
and facilitate the drug design process! Demonstrating the
achievements of the receptor-based approach in therapeutics and
indicating future directions, Receptor-Based Drug Design introduces
novel computer-assisted strategies for the design of new agonists,
antagonists, and inverse agonists for G-protein-coupled receptors
shows how to assess agonist concentration-effect curve data
discusses radioligand binding assays presents new in vitro
multiarray assays for G-protein-coupled receptors explains the use
of individual second messenger signaling responses in analyzing
drug-receptor interactions examines the role of electrophysiology
in finding new drugs and drug targets describes selectively acting
b-adrenoceptor agonists and glucocorticoid steroids for asthma
treatment outlines the rationale for using angiotensin receptor
antagonists and more! Written by over 25 international authorities
and containing nearly 1200 bibliographic citations, Receptor-Based
Drug Design is a practical resource for pharmacologists,
pharmacists, and pharmaceutical scientists; organic and medicinal
chemists and biochemists; molecular biologists; biomedical
researchers; and upper-level undergraduate and graduate students in
these disciplines.
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