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Myelin (Paperback, Softcover reprint of the original 1st ed. 1977)
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Myelin (Paperback, Softcover reprint of the original 1st ed. 1977)
Series: Advances in Neurochemistry
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The division of the mature mammalian brain and spinal cord into
regions of "white" matter and "gray" matter is observable upon the
most cursory inspection. Microscopic examination indicates that the
"white" matter regions are characterized by a multilamellar sheath
(myelin) which sur rounds the axons. A morphologically similar
myelin imparts the white color to tracts of the peripheral nervous
system, although, as is empha sized throughout the book, there are
very significant morphological and chemical differences between
central and peripheral myelin. The rapid postnatal accumulation of
myelin is temporally associated with increasing functional capacity
and presumably indicates some important role related to neuronal
activity. The ability of myelinated axons to conduct electrical
impulses much more rapidly and with much lower use of energy,
relative to unmyelinated axons, is now generally accepted. As is
evident from the above capsule description, a considerable body of
information concerning myelin is available. However, as in other
areas of research the unknown expands before us more rapidly than
we are able to add to our core of knowledge. This is a corollary of
the axiom that a good experiment raises more questions than it
answers. Among the areas currendy under investigation in many
laboratories are the following: interaction of myelin-forming cells
with neurons, assembly and metabo lism of myelin, molecular
architecture of myelin, and the details of the functional role of
myelin."
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