L-Asparaginase is widely used enzyme for the treatment of ALL and
thus its Production and activity plays a major role in its
therapeutic use. Screening of the different sources for prominent
L-Asn-ase production and high activity was done at different
physiological conditions and high yield of the enzyme was obtained.
The obtained enzyme from the two isolates are compared relatively
on the basis of Km and Vmax values and one of them is being found
to be more effective with low Km. This would serve as a good drug
if tested and certified clinically restricting the ALL.
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