New information is developing so rapidly in the entire field of
immunology that one is unable to remain abreast of all advancing
fronts. In many cases, consider able information has accumulated as
the result of the efforts of many investigators, but the
conclusions from the various laboratories have not been summarized
recently in a comprehensible manner. One such situation has to do
with work on IgD. An up-to-date report on this immunoglobulin was
included in Volume 10f this series, but since that time there has
been considerable progress in the deter mination of its structure
and function. In the present volume Leslie and Martin have reviewed
the accomplishments of recent years and the problems remaining to
be solved. New information regarding the concentration of IgD in
body fluids in normal and disease states is presented. Studies of
the ontogeny of surface IgD in animals are described, and the
fmdings imply that it may be important in the primary immune
response. The role of IgD on lymphocyte surfaces is thoroughly
discussed especially in terms of stimulating or suppressive
combinations of signals delivered to the lymphocyte by agents which
bind or alter the surface rt: ceptors. The authors conclude by
proposing a model for plasma-cell differentiation which accounts fo
the existence of triple Ig-bearing cells, many IgM-IgD-bearing
cells, and the low percentage of cells bearing a single isotype.
Sometimes the serum of an individual contains abnormally large
amounts of two distinct, homogeneous populations of
immunoglobulins."
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