Some general aspects of opiate dependence are described in a first
section including a brief historical description and an explanation
of the different models currently used to investigate opiate
dependence. The neurobiological bases of opiate withdrawal are
detailed in a second section, which particularly emphasizes the
neurophysiological adaptative changes, the processes of homologous
and heterologous regulation, and the role played by different brain
structures and several endogenous peptides acting as antiopiates.
The last part reports several basic aspects more directly related
to the clinical perspectives of opiate dependence, such as the new
expectations in the treatment of opiate withdrawal or the
relationships between sensitization, tolerance and withdrawal.
General
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