Cancer Genomics for the Clinician is a practical guide to cancer
genomics and its application to cancer diagnosis and care. The book
begins with a brief overview of the various types of genetic
alterations that are encountered in cancer, followed by accessible
and applicable information on next generation sequencing technology
and bioinformatics, tumor heterogeneity, whole genome, exome and
transcriptome sequencing, epigenomics, and data analysis and
interpretation. Each chapter provides essential explanations of
concepts, terminology, and methods. Also included are tips for
interpreting and analyzing molecular data, as well as a discussion
of molecular predictors for targeted therapies covering hematologic
malignancies and solid tumors. The final chapter explains the use
of FDA-approved genomic-based targeted therapies for breast cancer,
lung cancer, sarcomas, gastrointestinal cancers, urologic cancers,
head and neck cancer, thyroid cancer, and many more. Assembled in
an accessible format specifically designed for the non-expert, this
book provides the clinical oncologist, early career practitioner,
and trainee with an essential understanding of the molecular and
genetic basis of cancer and the clinical aspects that have led to
advancements in diagnosis and treatment. With this resource,
physicians and trainees will increase their breadth of knowledge
and be better equipped to educate patients and families who want to
know more about their genetic predispositions to cancer and the
targeted therapies that could be considered and prescribed. Key
Features: Describes how cancer genomics and next generation
sequencing informs cancer screening, risk factors, therapeutic
options, and clinical management across cancer types Explains what
mutations are, what tests are needed, and how to interpret the
results Provides information on FDA-approved targeted therapies
that are being used in the clinic Covers different sequencing
platforms and technologies and how they perform in research
settings Includes access to the fully-searchable downloadable eBook
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