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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Biochemical immunology
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Not currently available
Mif: A Most Interesting Factor (Hardcover)
Loot Price: R2,670
Discovery Miles 26 700
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Mif: A Most Interesting Factor (Hardcover)
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In recent years, researchers have identified a pivotal, upstream
role for macrophage migration inhibitory factor (MIF) in the innate
immune response. This pioneering book describes this renaissance of
knowledge in the biology of MIF. Topics covered include MIF's
molecular mechanism of action, its counterregulatory action on the
immunosuppressive properties of glucocorticoids, its role in the
production of proinflammatory mediators as shown in cell-based and
animal studies; and its central role in human inflammation. Human
genetic studies have identified allelic forms of the MIF gene, and
high-expression alleles have been associated with rheumatoid
arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel
disease, and other inflammatory and infectious maladies. The book
also discusses the role of MIF as a therapeutic target. Unique
structural features of the protein, such as an intrinsic catalytic
activity and the recent discovery of its cell surface receptor,
offer attractive opportunities for therapeutic intervention. Such
approaches are presently in clinical development.
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