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Advances in Targeted Cancer Therapy (Hardcover, 2005 ed.)
Loot Price: R5,586
Discovery Miles 55 860
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Advances in Targeted Cancer Therapy (Hardcover, 2005 ed.)
Series: Progress in Drug Research, 63
Expected to ship within 12 - 17 working days
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Volume 63 of "Progress in Drug Research" is devoted to recent
developments in targeted cancer therapy. Significant advances in
the fields of molecular and tumor biology over the past decade have
led to this exciting new era in c- cer therapeutics with an
intensive effort in rationally-designed cancer the- peutic
strategies directed against selective molecular targets. These
selective approaches may ultimately lead to tailoring treatments to
individual patients where molecular biomarkers of sensitivity to
therapy are identified, prod- ing better tolerated therapies with
less side effects than past experiences with cytotoxic cancer
chemotherapy, and reducing cancer to a controlled, chronic state.
This volume contains eleven chapters, including updated reviews on
a range of targets, such as tumor angiogenesis, apoptosis/cell
survival pa- ways, and various inhibitors of cyclin-dependent
kinases, cyclooxygenase-2 (COX-2), epidermal growth factor receptor
(EGFR), and histone deacetylases (HDAC). Additional topics,
including target validation, polypharmacology and potential synergy
of involving multiple targets, antisense approaches, animal models
for preclinical development of targeted agents, and obstacles,
including development of resistance are also presented. In
addition, the p- ticular challenges involved in translating
preclinical data to clinical appli- tion are discussed. It gives me
great pleasure to present this new volume. I would like to express
my gratitude to the chapter authors, to Birkhauser Verlag and, in
particular, to Dr. Beatrice Menz and Ms. Gabriele Poppen for their
assistance in compiling and editing this volume. April 2005 Richard
M. Schultz vii Progress in Drug Research, Vol. 63 (R. M. Schultz,
Ed.
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