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International Symposium: Retroviruses and Human Pathology (Paperback, Softcover reprint of the original 1st ed. 1985)
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International Symposium: Retroviruses and Human Pathology (Paperback, Softcover reprint of the original 1st ed. 1985)
Series: Experimental Biology and Medicine, 11
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For decades retroviruses have been riding the crest of a wave of
experimental research directed toward the identification of an
infectious agent of human neoplastic diseases. In the early 1970s,
several scientists successfully demonstrated the presence of
retroviruses in numerous animal species and proved their
etiological role in some related diseases. Corresponding findings
in humans were somewhat discouraging. Although financial support
for this line. of research declined, a few dedicated
retrovirologists survived and continued to collect more biological
information and technological expertise that opened a new approach
to the search for a human retrovirus. The rewards came with the
discovery that the genes responsible for neoplastic transformation
(oncogenes) are of cellular origin and can be shuttled about by
retroviruses, and with the identification of a new family of Human
T-cell Lymphotrophic retroViruses (HTLV) from patients with
diseases ranging from leukemia to the acquired immunodeficiency
syndrome (AIDS). An understanding of the role and significance of
retroviruses in human pathology requires basic knowledge of the
major animal systems studied. With this perspective in mind, we
present here a survey that includes general overviews, minireviews
on each animal system studied with selected experimental reports
and, finally, a stimulating review of the field of human
retrovirology by many of the pioneer scientists who created it. We
are especially grateful to Profs. C. A. Romanzi and G. C. Schito
for promoting the organization of the Symposium. On behalf of the
Sym posium Committee, we thank E. Soeri, L. Casarino, G. P. Gesu,
M."
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