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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Molecular and Clinical Advances in Anticancer Drug Resistance (Paperback, Softcover reprint of the original 1st ed. 1991)
Loot Price: R5,518
Discovery Miles 55 180
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Molecular and Clinical Advances in Anticancer Drug Resistance (Paperback, Softcover reprint of the original 1st ed. 1991)
Series: Cancer Treatment and Research, 57
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The importance of drug resistance in cancer chemotherapy cannot be
over stated. The 500,000 patients who die every year from cancer in
the United States have, in most cases, been treated with
chemotherapy. Many of these patients responded initially to
chemotherapy, but death resulted from the development of
drug-resistant tumors. In the first volume in the series. Drug
Resistance in Chemotherapy the results of comprehensive laboratory
studies aimed at understanding the mechanisms for resistance to
individual agents and to the development of broad cross-resistance
were described. In the past 2 years there has been substantial
progress in understanding the molecular biology associated with
these mechanisms of drug resistance. For the first time we are
starting to understand which mechanisms are playing an im portant
role in human tumors, and even more importantly, clinical trials
have recently been initiated in an effort to reverse specific forms
of drug resistance. The purpose of this volume is to describe the
new advances, both at the molecular level and in the clinic
regarding mechanisms of drug resistance and potential ways this
resistance can be circumvented. This volume is focused upon
mechanisms of resistance associated with two major classes of
anticancer drugs: alkylating agents (including cisplatin) and the
natural products (e. g., adriamycin and vinblastine). The first
section of the book describes new insights into the genetic
mechanisms associated with drug resistance."
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