Exocytosis is a fundamental cellular process that is used by
eukaryotic cells to release a variety of biological compounds
including peptide hormones and neurotransmitters or to insert
specific lipids and proteins in the plasma membrane. In recent
years, a multidisciplinary approach promoted an extraordinary
progress in the understanding of the molecular mechanisms
regulating exocytosis. This led to the discovery of a large number
of components belonging to the machinery that governs the fusion of
secretory vesicles with plasma membranes in different cell systems,
including neuronal and endocrine cells. The basic machinery
required for vesicle fusion turned out to be well conserved through
evolution from yeast to man. So far, because of the large number of
components involved, understanding of the molecular basis of
exocytosis has remained the privilege of a relatively small group
of specialists. This book, written by recognized experts in the
field aims at clarifying for a non-specialist audience the role of
the key players in the exocytotic process not only in neuronal and
endocrine cells but also in a variety of other relevant cell
systems. The book represents a unique collection of up-to-date
reviews that will introduce researchers and students to the
forefront of this rapidly moving and fascinating field.
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