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Development of Innovative Drugs via Modeling with MATLAB - A Practical Guide (Paperback, Softcover reprint of the original 1st ed. 2014)
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Development of Innovative Drugs via Modeling with MATLAB - A Practical Guide (Paperback, Softcover reprint of the original 1st ed. 2014)
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The development of innovative drugs is becoming more difficult
while relying on empirical approaches. This inspired all major
pharmaceutical companies to pursue alternative model-based
paradigms. The key question is: How to find innovative compounds
and, subsequently, appropriate dosage regimens? Written from the
industry perspective and based on many years of experience, this
book offers: - Concepts for creation of drug-disease models,
introduced and supplemented with extensive MATLAB programs -
Guidance for exploration and modification of these programs to
enhance the understanding of key principles - Usage of differential
equations to pharmacokinetic, pharmacodynamic and (patho-)
physiologic problems thereby acknowledging their dynamic nature - A
range of topics from single exponential decay to adaptive dosing,
from single subject exploration to clinical trial simulation, and
from empirical to mechanistic disease modeling. Students with an
undergraduate mathematical background or equivalent education,
interest in life sciences and skills in a high-level programming
language such as MATLAB, are encouraged to engage in model-based
pharmaceutical research and development.
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