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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Biological Methylation and Drug Design - Experimental and Clinical Role of S-Adenosylmethionine (Hardcover, 1986 ed.)
Loot Price: R5,654
Discovery Miles 56 540
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Biological Methylation and Drug Design - Experimental and Clinical Role of S-Adenosylmethionine (Hardcover, 1986 ed.)
Series: Experimental Biology and Medicine, 12
Expected to ship within 10 - 15 working days
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This book has been developed from its earlier and far less formal
presentment as the proceedings of a symposium entitled The
Biochemistry of S-Adenosylmethionine as a Basis for Drug Design
that was held at the Solstrand Fjord Hotel in Bergen, Norway on
June 30-July 4, 1985. The purpose of the symposium was to bring
together scientists from various disciplines (biochemistry,
pharmacology, virology, immunology, chemistry, medicine, and so on)
to discuss the recent advances that have been made in our
understanding of the biological roles of S adenosylmethionine
(AdoMet) and to discuss the feasibility of utilizing
AdoMet-dependent enzymes as targets for drug design. Thus the
information provided herein will be of value not only to basic
scientists involved in elucidating the role of AdoMet in biology,
but also to medicinal chemists who are using this basic knowledge
in the process of drug design. The volume should also be of
interest to pharmacologists and clinicians involved in biological
evaluation of potential therapeutic agents arising from the efforts
of the biochemists and medicinal chemists. Each plenary speaker at
the symposium was requested to submit a chapter reviewing recent
contributions of their discipline to our base of knowledge about
the biological role of AdoMet. Topics covered in this volume
include protein and phospholipid methylations (Section A), nucleic
acid methyl ations (Section B), the regulation of AdoMet,
S-adenosylhomocysteine, and methylthioadenosine metabolism (Section
C), clinical aspects of AdoMet (Section D), and the design,
synthesis, and biological evaluation of trans methylation
inhibitors (Section E)."
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