The need in healthcare to detect biomolecular species such as
proteins, oligonucleotides (DNA and RNA) and cells for diagnostics
is driving the current development of physical techniques. The
development is generally based on optical, electrochemical and mass
spectrometric transduction to enable these measurements. These are
now also being exploited in array formats, enabling the development
of high throughput detection to inform systems biology and pathway
medicine by giving new insights into biomolecular pathways and the
identification of new target analytes. This is a highly topical and
exciting area which opens up the real prospect of theranostics (the
use of diagnostics in informing patient specific therapy), but for
which development and optimisation of detection requires an
understanding and control of the fundamental physical processes
occurring both in sensing and in signal transduction and the
comparatives merits of alternative detection strategies. For high
throughput detection, bioinformatics (the processing and
interpretation of vast amounts of data) also presents a real
challenge. Faraday Discussion 149 is organised by the Faraday
Division in association with the Analytical Division.
General
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