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D-Amino Acids - Practical Methods & Protocols -- Volume 4: Enzymes Involved in the Metabolism of D-Amino Acids (Hardcover)
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D-Amino Acids - Practical Methods & Protocols -- Volume 4: Enzymes Involved in the Metabolism of D-Amino Acids (Hardcover)
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D-Amino acids are stereoisomers or optical isomers of naturally
occurring L-amino acids. D Amino acids and L-amino acids have
almost the same physical and chemical properties. D-Amino acids
have been considered to be unnatural substances that are produced
only when we synthesize amino acids in laboratories or factories.
Indeed, equal amounts of D-amino acids and L-amino acids (racemic
mixture) are produced by chemical synthesis. Until recently, living
organisms were thought to contain exclusively L-amino acids. Before
the emergence of life, D- and L-amino acids should have existed on
the primitive earth, because amino acids are considered to be
produced under the conditions of high temperature, high pressure
and lightning. It is an interesting and important question why
D-amino acids were eliminated and organisms have evolved using only
L-amino acids. This mystery has not been solved. D-Amino acids have
been considered exceptional amino acids that exist only in
prokaryotes and a part of lower organisms. However, the development
and improvement of analytical instruments and methods have revealed
that D-amino acids are present in organisms far more in the amount
and extent than previously considered. It has become clear that
D-amino acids are present in invertebrates and vertebrates
including humans and that some of D-amino acids have important
physiological functions. Biological systems for synthesis and
degradation of D-amino acids have also been found. This volume is
dedicated to analytical methods for the enzymes involved in the
metabolism of D-Amino Acids.
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