Aberrant expression and function of microRNAs (miRNAs) in cancer
have added a new layer of complexity to the understanding of
development and progression of the disease state. It has been
demonstrated that miRNAs have a crucial function in oncogenesis by
regulating cell proliferation and apoptosis as oncogenes or tumor
suppressors. The expression signatures of miRNAs provide exciting
opportunities in the diagnosis, prognosis and therapy of cancer.
Since miRNAs can function as either oncogenes or tumor suppressor
genes in oncogenesis, the potential of using these small RNAs as
therapeutic targets opens up new opportunities for cancer therapy
by either inhibiting or augmenting their activity.
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