The World Health Organization has identified chronic alcohol
consumption as one of the top ten risk factors for worldwide burden
of disease. The International Agency for Research on Cancer has
identified alcohol as carcinogenic to humans, including cancers of
the upper aerodigestive tract, colon, liver and breast. Alcohol's
actions may be direct e.g. effects on retinoic acid and one-carbon
metabolism, or indirect, through metabolites such as acetaldehyde
and reactive oxygen species or through various signaling pathways
that influence cell cycle and apoptosis that may contribute to
carcinogenesis. This report reviews the state of the art in
alcohol-related cancer research in ten chapters.
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