In her thesis, Sara Bobone outlines spectroscopic studies of
antimicrobial peptides (AMPs) which are promising lead compounds
for drugs used to fight multidrug resistant bacteria. Bobone shows
that AMPs interact with liposomes and she clarifies the structure
of pores formed by one of these molecules. These results help us to
understand how AMPs are selective for bacterial membranes and how
their activity can be finely tuned by modifying their sequence.
Findings which solve several conundrums debated in the literature
for years. In addition, Bobone uses liposomes as nanotemplates for
the photopolymerization of hydrogels - exploiting the self-
assembly properties of phospholipids. Bobone was able to trap an
enzyme using nanometeric particles, while still allowing its
activity by the diffusion of substrates and products through the
network of the polymer. The innovative nano devices described in
this thesis could solve many of the hurdles still hampering the
therapeutic application of protein-based drugs.
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