Epigenetics is the study of both heritable and non-heritable
changes in the regulation of gene activity and expression that
occur without an alteration in the DNA sequence. This dynamic and
rapidly developing discipline is making its impact across the
biomedical sciences, in particular in toxicology where epigenetic
differences can mean that different individuals respond differently
to the same drug or chemical.
"Toxicology and Epigenetics" reflects the multidimensional
character of this emerging area of toxicology, describing
cutting-edge molecular technologies to unravel epigenetic changes,
the use of "in vivo" and "in vitro "models, as well as the
potential use of toxicological epigenetics in regulatory
environments. An international team of experts consider the
interplay between epigenetics and toxicology in a number of areas,
including environmental, nutritional, pharmacological, and
computational toxicology, nanomaterials, proteomics and
metabolomics, and cancer research.
Topics covered include: environment, epigenetics and diseasesDNA
methylation and toxicogenomics chromatin at the intersection of
disease and therapyepigenomic actions of environmental
arsenicalsenvironment, epigenetics and cardiovascular
healthtoxicology, epigenetics and autoimmunityocular epigenomics:
potential sites of environmental impact in development and
diseasenuclear RNA silencing and related phenomena in
animalsepigenomics - impact for drug safety sciencesmethods of
global epigenomic profilingtranscriptomics: applications in
epigenetic toxicology
"Toxicology and Epigenetics" is an essential insight into the
current trends and future directions of research in this rapidly
expanding field for investigators, toxicologists, risk assessors
and regulators in academia, industry and government.
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