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Applying Toponome Imaging System to Colon Cancer (Paperback)
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Applying Toponome Imaging System to Colon Cancer (Paperback)
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In this proof of principle study, automated fluorescence Toponome
Imaging System (TIS) was applied to find protein network structures
distinguishing cancer tissue from normal colon tissue, taken from
the same patient. Cancer specimen and corresponding normal tissue
were harvested at colectomy from a single patient and prepared for
TIS using a battery of different antibodies, including a number of
putative stem cell markers. Expression of multiple protein clusters
was determined and Combinatorial Molecular Phenotypes (CMPs) were
analysed, using specific image-analysis tools. By sub-cellular
visualization procedures it was found, that many cell surface
membrane molecules were closely associated with cell-cytoskeleton
as unique CMPs in the normal part of colon, while the same
molecules were disassembled in the cancerous part, suggesting
dysfunctional cytoskeleton-membrane complexes. Glandular and
Stromal cell signatures were found, but interestingly also found
were few TIS signatures identifying a very restricted subset of
cells, expressing several putative stem cell markers, all
restricted to the cancerous tissue.
General
Imprint: |
Lap Lambert Academic Publishing
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Country of origin: |
Germany |
Release date: |
July 2012 |
First published: |
July 2012 |
Authors: |
Sayan Bhattacharya
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Dimensions: |
229 x 152 x 12mm (L x W x T) |
Format: |
Paperback - Trade
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Pages: |
212 |
ISBN-13: |
978-3-659-18009-5 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
General
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LSN: |
3-659-18009-2 |
Barcode: |
9783659180095 |
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